Accelerating research on biological aging and mental health: Current challenges and future directions

PSYCHONEUROENDOCRINOLOGY

卷:106

Article

Han, Laura K. M.^1,2  Verhoeven, Josine E.¹  Tyrka, Audrey R.^3,4  Penninx, Brenda W. J. H.^1,2  Wolkowitz, Owen M.^5,6  Mansson, Kristoffer N. T.^7,8,9  Lindqvist, Daniel^5,10,11  Boks, Marco P.¹²  Revesz, Dora¹³  Mellon, Synthia H.^5,6  Picard, Martin^14,15,16 

[1] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Oldenaller 1, Netherlands

[2] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Psychiat, Boelelaan 1117, Amsterdam, Netherlands

[3] Brown Univ, Butler Hosp, Providence, RI 02912 USA

[4] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA

[5] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA USA

[6] Univ Calif San Francisco, Sch Med, Weill Inst Neurosci, San Francisco, CA USA

[7] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[8] Stockholm Univ, Dept Psychol, Stockholm, Sweden

[9] Uppsala Univ, Dept Psychol, Uppsala, Sweden

[10] Lund Univ, Dept Clin Sci, Fac Med, Psychiat, Lund, Sweden

[11] Psychiat Clin, Div Psychiat, Lund, Sweden

[12] Univ Med Ctr Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands

[13] Tilburg Univ, Dept Med & Clin Psychol, Ctr Res Psychol Somat Dis CoRPS, Tilburg, Netherlands

[14] Columbia Univ, Med Ctr, Div Behav Med, Dept Psychiat, New York, NY 10027 USA

[15] Columbia Univ, Med Ctr, Columbia Translat Neurosci Initiat, Dept Neurol,H Houston Merritt Ctr, New York, NY USA

[16] Columbia Univ, Columbia Aging Ctr, New York, NY USA

关键词: Biological age;    Psychopathology;    DNA methylation;    Brain;    Mitochondria;    Telomere length;   

DOI  :  10.1016/j.psyneuen.2019.04.004

来源: Elsevier

【 摘 要 】

Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1) establishing the best objective and predictive biological age indicators or combinations of indicators, 2) identifying the basis for inter-individual differences in the rate of biological aging, and 3) examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging.

【 授权许可】

Free