Genetic and environmental causes of variation in epigenetic aging across the lifespan

Clinical Epigenetics

Tuong L. Nguyen¹  Gillian S. Dite¹  John L. Hopper¹  Shuai Li²  Pierre-Antoine Dugué³  Graham G. Giles³  Roger L. Milne³  Anbupalam Thalamuthu⁴  Perminder S. Sachdev⁵  Karen A. Mather⁵  Jeffrey M. Craig⁶  Qihua Tan⁷  Joohon Sung⁸  Nicola J. Armstrong⁹  Richard Saffery^1,10  Ee Ming Wong^1,11  Melissa C. Southey^1,12 

[1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3051, Parkville, VIC, Australia;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3051, Parkville, VIC, Australia;Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK;Precision Medicine, School of Clinical Sciences At Monash Health, Monash University, Clayton, VIC, Australia;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3051, Parkville, VIC, Australia;Precision Medicine, School of Clinical Sciences At Monash Health, Monash University, Clayton, VIC, Australia;Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia;Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia;Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia;Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia;Centre for Molecular and Medical Research, School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, VIC, Australia;Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark;Institute of Health and Environment, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Korea;Mathematics and Statistics, Murdoch University, Perth, WA, Australia;Murdoch Childrens Research Institute, Parkville, VIC, Australia;Precision Medicine, School of Clinical Sciences At Monash Health, Monash University, Clayton, VIC, Australia;Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia;Precision Medicine, School of Clinical Sciences At Monash Health, Monash University, Clayton, VIC, Australia;Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia;Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia;

关键词: Aging;    Epigenetic aging;    Biological age;    Epigenetic clock;    DNA methylation;    Twin study;   

DOI  :  10.1186/s13148-020-00950-1

来源: Springer

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