BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia

PSYCHONEUROENDOCRINOLOGY

卷:80

Article

Lopez-Granero, Caridad^1,2  dos Santos, Alessandra Antunes¹  Ferrer, Beatriz¹  Culbreth, Megan¹  Chakraborty, Sudipta¹  Barrasa, Angel²  Gulinello, Maria³  Bowman, Aaron B.^4,5,6,7  Aschner, Michael¹ 

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[2] Univ Zaragoza, Dept Psicol & Sociol, Campus Ciudad Escolar, Teruel 44003, Spain

[3] Albert Einstein Coll Med, Dept Neurosci, Behav Core Facil, Bronx, NY 10461 USA

[4] Vanderbilt Univ, Dept Pediat, Nashville, TN USA

[5] Vanderbilt Univ, Dept Neurol, 221 Kirkland Hall, Nashville, TN 37235 USA

[6] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

[7] Vrije Univ Amsterdam Med Ctr, Nashville, TN USA

关键词: BXD RI mice;    Anxiety;    Depression;    Nrf2;    Inflammation;    Cytokines;   

DOI  :  10.1016/j.psyneuen.2017.03.006

来源: Elsevier

【 摘 要 】

Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers. Specifically, we assessed social preference, elevated plus maze, forced swim, and Von Frey tests at 3-4 months-of-age, as well as activation of cytokines and antioxidant mRNA levels in the cortex at 7 months-of-age. We report that (1) the BXD84/RwwJ RI strain exhibits anxiety disorder and social avoidance-like behavior (2) BXD21/TyJ RI strain shows a resistance to depression illness, and (3) sex-dependent cytokine profiles and allodynia with elevated inflammatory activity were inherent to male BXD21/TyJ RI mice. In conclusion, we provide novel data in favor of the use of BXD recombinant inbred mice to further understand anxiety and depression disorders. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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