Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation

卷:39

Zhang, Ji-Chun ; Yao, Wei ; Dong, Chao ; Yang, Chun ; Ren, Qian ; Ma, Min ; Han, Mei ; Wu, Jin ; Ushida, Yusuke ; Suganuma, Hiroyuki ; Hashimoto, Kenji

Chiba Univ

关键词: Brain-derived neurotrophic factor;    Depression;    Inflammation;    Nrf2;    Prevention;    Sulforaphane;    Synaptogenesis;   

DOI  :  10.1016/j.jnutbio.2016.10.004

学科分类：食品科学和技术

【 摘 要 】

Inflammation plays a role in the pathophysiology of depression. Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation. In this study, we examined whether the prevention effects of SFN in lipopolysaccharide (LPS) induced depression-like behavior in mice. Pretreatment with SFN significantly blocked an increase in the serum tumor necrosis factor-alpha (TNF-alpha) level and an increase in microglial activation of brain regions after a single administration of LPS (0.5 mg/kg). Furthermore, SFN significantly potentiated increased serum levels of IL-10 after LPS administration. In the tail-suspension test and forced swimming test, SFN significantly attenuated an increase of the immobility time after LPS administration. In addition, SFN significantly recovered to control levels for LPS-induced alterations in the proteins such as brain-derived neurotrophic factor, postsynaptic density protein 95 and AMPA receptor 1 (GluA1) and dendritic spine density in the brain regions. Finally, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food during the juvenile and adolescence could prevent the onset of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions at adulthood. In conclusion, these findings suggest that dietary intake of SFN-rich broccoli sprout has prophylactic effects on inflammation-related depressive symptoms. Therefore, supplementation of SFN-rich broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients. (C) 2016 Elsevier Inc. All rights reserved.