Stress and genetics influence hair cortisol in FMR1 premutation carrier mothers of children with fragile X syndrome

PSYCHONEUROENDOCRINOLOGY

卷:129

Article

Hong, Jinkuk¹  Kapoor, Amita²  DaWalt, Leann Smith¹  Maltman, Nell¹  Kim, Bryan¹  Berry-Kravis, Elizabeth M.³  Almeida, David⁴  Coe, Christopher⁵  Mailick, Marsha¹ 

[1] Univ Wisconsin, Waisman Ctr, Madison, WI 53706 USA

[2] Univ Wisconsin Madison, Wisconsin Natl Primate Res Ctr, Madison, NJ USA

[3] Rush Univ Med Ctr, Chicago, IL 60612 USA

[4] Penn State Univ, Dept Human Dev & Family Stud, University Pk, PA USA

[5] Univ Wisconsin Madison, Dept Psychol, Madison, NJ USA

关键词: FMR1 Premutation;    Hair cortisol;    Salivary cortisol;    HPA functioning;    Adverse life events;   

DOI  :  10.1016/j.psyneuen.2021.105266

来源: Elsevier

【 摘 要 】

To investigate genetic and environmental influences on cortisol levels, mothers of children with fragile X syndrome (FXS) were studied four times over a 7.5-year period. All participants (n = 84) were carriers of the FMR1 premutation, a genetic condition associated with impaired HPA axis functioning. Genetic variation was indicated by expansions in the number of CGG (cytosine-guanine-guanine) repeats in the FMR1 gene (67-138 repeats in the present sample). The environmental factor was cumulative exposure to adverse life events during the study period. Cortisol was measured at the beginning of the study via saliva samples and at the end of the study via hair samples; hormone values from these two specimen types were significantly correlated. The interactions between CGG repeat number and adverse life events significantly predicted hair cortisol concentration, including after accounting for the initial salivary cortisol level. For those with fewer CGG repeats, stress exposure was associated with elevated cortisol, the expected response to stress, although women with a higher number of CGGs had a reduced cortisol response to adverse events, which might be related to HPA dysfunction. These results indicate that both exogenous and endogenous factors affect HPA functioning in this population of women.

【 授权许可】

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