Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins

PSYCHONEUROENDOCRINOLOGY

卷:66

Article

Ouellet-Morin, Isabelle^1,2  Brendgen, Mara^3,4  Girard, Alain⁴  Lupien, Sonia J.^2,5  Dionne, Ginette⁶  Vitaro, Frank^4,7  Boivin, Michel^6,8 

[1] Univ Montreal, Sch Criminol, Montreal, PQ, Canada

[2] Montreal Mental Hlth Univ Inst, Res Ctr, Montreal, PQ, Canada

[3] Univ Quebec, Dept Psychol, Montreal, PQ H3C 3P8, Canada

[4] St Justine Hosp, Res Ctr, Montreal, PQ, Canada

[5] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada

[6] Univ Laval, Dept Psychol, Quebec City, PQ, Canada

[7] Univ Montreal, Sch Psychoeduc, Montreal, PQ, Canada

[8] Tomsk State Univ, Inst Genet Neurobiol & Social Fdn Child Dev, Tomsk, Russia

关键词: HPA axis;    Cortisol;    Diurnal rhythm;    Genes;    Twin studies;    Cortisol awakening response;   

DOI  :  10.1016/j.psyneuen.2015.12.022

来源: Elsevier

【 摘 要 】

Introduction: By and large, studies have reported moderate contributions of genetic factors to cortisol secreted in the early morning and even smaller estimates later in the day. In contrast, the cortisol awakening response (CAR) has shown much stronger heritability estimates, which prompted the hypothesis that the etiology of cortisol secretion may vary according to the time of day. A direct test of this possibility has, however, not yet been performed. Objective: To describe the specific and common etiology of the CAR, awakening level and cortisol change from morning to evening in an age-homogenous sample of twin adolescents. Methods: A total of 592 participants of the Quebec Newborn Twin Study, a population-based 1995-1998 cohort of families with twins in Canada, have collected saliva at awakening, 30 min later, at the end of afternoon and in the evening over four collection days. Results: Multivariate Cholesky models showed both specific and common sources of variance between the CAR, awakening and cortisol diurnal change. The CAR had the strongest heritability estimates, which, for the most part, did not overlap with the other indicators. Conversely, similar magnitudes of genetic and environmental contributions were detected at awakening and for diurnal change, which partially overlapped. Conclusion: Our study unraveled differences between the latent etiologies of the CAR and the rest of the diurnal cycle, which may contribute to identify regulatory genes and environments and detangle how these indicators each relate to physical and mental health. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free