The CIRCORT database: Reference ranges and seasonal changes in diurnal salivary cortisol derived from a meta-dataset comprised of 15 field studies

PSYCHONEUROENDOCRINOLOGY

卷:73

Article

Miller, Robert¹  Stalder, Tobias¹  Jarczok, Marc²  Almeida, David M.³  Badrick, Ellena⁴  Bartels, Meike⁵  Boomsma, Dorret I.⁵  Coe, Christopher L.⁶  Dekker, Marieke C. J.⁷  Donzella, Bonny⁸  Fischer, Joachim E.²  Gunnar, Megan R.⁸  Kumari, Meena¹⁰  Lederbogen, Florian¹¹  Power, Christine⁹  Ryff, Carol D.⁶  Subramanian, S. V.¹²  Tiemeier, Henning^7,13  Watamura, Sarah E.¹⁴  Kirschbaum, Clemens¹ 

[1] Tech Univ Dresden, Inst Gen Psychol Biopsychol & Psychol Methods, Zellescher Weg 19, D-01069 Dresden, Germany

[2] Mannheim Inst Publ Hlth, Ludolf Krehl Str 7-11, D-68167 Mannheim, Germany

[3] Penn State Univ, Coll Heath & Human Dev, University Pk, PA 16802 USA

[4] Univ Manchester, Farr Inst Hlth Informat Res, MRC Hlth eRes Ctr, Oxford Rd, Manchester M13 9PL, Lancs, England

[5] Vrije Univ Amsterdam, Dept Biol Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands

[6] Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA

[7] Erasmus MC, Dept Epidemiol, Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands

[8] Univ Minnesota, Inst Child Dev, 51 East River Pkwy, Minneapolis, MN 55455 USA

[9] UCL, UCL Inst Child Hlth, Populat Policy & Practice, 30 Guilford St, London WC1N 1EH, England

[10] Univ Essex, ISER, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England

[11] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, J5, D-68159 Mannheim, Germany

[12] Harvard Sch Publ Hlth, Dept Soc Human Dev & Hlth, 677 Huntington Ave, Boston, MA 02115 USA

[13] Erasmus MC, Dept Psychiat, Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands

[14] Univ Denver, Dept Psychol, 2155S Race St, Denver, CO 80208 USA

关键词: Cortisol;    Saliva;    Reference value;    Circadian rhythm;    Lifespan;   

DOI  :  10.1016/j.psyneuen.2016.07.201

来源: Elsevier

【 摘 要 】

Diurnal salivary cortisol profiles are valuable indicators of adrenocortical functioning in epidemiological research and clinical practice. However, normative reference values derived from a large number of participants and across a wide age range are still missing. To fill this gap, data were compiled from 15 independently conducted field studies with a total of 104,623 salivary cortisol samples obtained from 18,698 unselected individuals (mean age: 48.3 years, age range: 0.5-98.5 years, 39% females). Besides providing a descriptive analysis of the complete dataset, we also performed mixed-effects growth curve modeling of diurnal salivary cortisol (i.e., 1-16h after awakening). Cortisol decreased significantly across the day and was influenced by both, age and sex. Intriguingly, we also found a pronounced impact of sampling season with elevated diurnal cortisol in spring and decreased levels in autumn. However, the majority of variance was accounted for by between-participant and between-study variance components. Based on these analyses, reference ranges (LC/MS-MS calibrated) for cortisol concentrations in saliva were derived for different times across the day, with more specific reference ranges generated for males and females in different age categories. This integrative summary provides important reference values on salivary cortisol to aid basic scientists and clinicians in interpreting deviations from the normal diurnal cycle. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free