Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention

PSYCHONEUROENDOCRINOLOGY

卷:74

Article

Casanova, Ramon¹  Hayasaka, Satoru²  Saldana, Santiago¹  Bryan, Nick R.³  Demos, Kathryn E.⁴  Desiderio, Lisa³  Erickson, Kirk I.⁵  Espeland, Mark A.¹  Nasrallah, Ilya M.³  Wadden, Thomas⁶  Laurienti, Paul J.⁷ 

[1] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA

[2] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[3] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[4] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Miriam Hosp Providence, Providence, RI 02912 USA

[5] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[6] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[7] Wake Forest Sch Med, Dept Radiol, Winston Salem, NC USA

关键词: Resting-state fMRI;    Functional connectivity;    Type 2 diabetes mellitus;    Weight-loss intervention;    Brain networks;   

DOI  :  10.1016/j.psyneuen.2016.09.016

来源: Elsevier

【 摘 要 】

A number of studies have reported that type 2 diabetes mellitus (T2DM) is associated with alterations in resting-state activity and connectivity in the brain. There is also evidence that interventions involving physical activity and weight loss may affect brain functional connectivity. In this study, we examined the effects of nearly 10 years of an intensive lifestyle intervention (ILI), designed to induce and sustain weight loss through lower caloric intake and increased physical activity, on resting-state networks in adults with T2DM. We performed a cross-sectional comparison of global and local characteristics from functional brain networks between individuals who had been randomly assigned to ILI or a control condition of health education and support. Upon examining brain networks from 312 participants (average age: 68.8 for ILI and 67.9 for controls), we found that ILI participants (N = 160) had attenuated local efficiency at the network-level compared with controls (N = 152). Although there was no group difference in the network-level global efficiency, we found that, among ILI participants, nodal global efficiency was elevated in left fusiform gyrus, right middle frontal gyrus, and pars opercularis of right inferior frontal gyrus. These effects were age-dependent, with more pronounced effects for older participants. Overall these results indicate that the individuals assigned to the ILI had brain networks with less regional and more global connectivity, particularly involving frontal lobes. Such patterns would support greater distributed information processing. Future studies are needed to determine if these differences are associated with age-related compensatory function in the ILI group or worse pathology in the control group. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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