Gene expression associated with individual variability in intrinsic functional connectivity

NeuroImage

Yongbin Wei¹  Liman Man Wai Li²  Yangyang Yi³  Zhengjia Dai³  Liangfang Li³  Junji Ma³  Yue Gu³  Jinbo Zhang³  Ying Lin³ 

[1] Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands;Department of Psychology and Centre for Psychosocial Health, The Education University of Hong Kong, Hong Kong SAR, China;Department of Psychology, Sun Yat-sen University, Guangzhou 510006, China;

关键词: Intersubject variability;    Functional connectivity;    Resting-state fMRI;    Gene expression;    Metabolism;   

DOI  :  

来源: DOAJ

【 摘 要 】

It has been revealed that intersubject variability (ISV) in intrinsic functional connectivity (FC) is associated with a wide variety of cognitive and behavioral performances. However, the underlying organizational principle of ISV in FC and its related gene transcriptional profiles remain unclear. Using resting-state fMRI data from the Human Connectome Project (299 adult participants) and microarray gene expression data from the Allen Human Brain Atlas, we conducted a transcription-neuroimaging association study to investigate the spatial configurations of ISV in intrinsic FC and their associations with spatial gene transcriptional profiles. We found that the multimodal association cortices showed the greatest ISV in FC, while the unimodal cortices and subcortical areas showed the least ISV. Importantly, partial least squares regression analysis revealed that the transcriptional profiles of genes associated with human accelerated regions (HARs) could explain 31.29% of the variation in the spatial distribution of ISV in FC. The top-related genes in the transcriptional profiles were enriched for the development of the central nervous system, neurogenesis and the cellular components of synapse. Moreover, we observed that the effect of gene expression profile on the heterogeneous distribution of ISV in FC was significantly mediated by the cerebral blood flow configuration. These findings highlighted the spatial arrangement of ISV in FC and their coupling with variations in transcriptional profiles and cerebral blood flow supply.

【 授权许可】

Unknown