A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants

PSYCHONEUROENDOCRINOLOGY

卷:124

Article

Rosin, Samuel¹  Xia, Kai²  Azcarate-Peril, M. Andrea^3,4  Carlson, Alexander L.²  Propper, Cathi B.⁵  Thompson, Amanda L.^6,7  Grewen, Karen²  Knickmeyer, Rebecca C.^2,8,9,10 

[1] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA

[2] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[3] Univ N Carolina, Dept Med, Chapel Hill, NC USA

[4] Univ N Carolina, Microbiome Core Facil, Chapel Hill, NC USA

[5] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC USA

[6] Univ N Carolina, Dept Anthropol, Chapel Hill, NC USA

[7] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA

[8] Michigan State Univ, Dept Pediat & Human Dev, E Lansing, MI 48824 USA

[9] Michigan State Univ, Inst Quantitat Hlth Sci & Engn, E Lansing, MI USA

[10] Michigan State Univ, E Lansing, MI 48824 USA

关键词: Gut microbiome;    HPA axis;    Cortisol reactivity;    Infant stress response;    Alpha diversity;   

DOI  :  10.1016/j.psyneuen.2020.105046

来源: Elsevier

【 摘 要 】

The Hypothalamic Pituitary Adrenal (HPA) axis regulates hormonal responses to stress in both humans and animals and is dysregulated in a wide range of psychiatric disorders. There is strong evidence from rodent studies that gut microbial composition influences HPA axis development. In humans, variation in the gut microbiome has been associated with several psychological domains including depression and cognitive development, but studies focused on HPA axis development are still lacking. We tested whether differences in microbial composition are associated with HPA axis reactivity in a pilot study of 34 healthy human infants. HPA axis reactivity was assessed by measuring salivary cortisol in samples taken both before and after a heel stick, and 16S rRNA amplicon sequencing was used for identification and relative quantification of bacterial taxa. Subjects' alpha diversity levels showed a moderate positive association with their cortisol reactivity at one month of age. Exploratory genus-level analyses suggest that Staphylococcus, Prevotella, and genera in the order Lachnospiraceae may be related to cortisol reactivity at one month as well. The current study gives support for the endocrine pathway as a potential mediator in the microbiome-gut-brain axis during infancy, and as such provides motivation for future clinical work to support the development of stress-response systems through the manipulation of gut microbes.

【 授权许可】

Free