EFFECTS OF EARLY PRENATAL DEXAMETHASONE ON THE COGNITIVE AND BEHAVIORAL-DEVELOPMENT OF YOUNG-CHILDREN - RESULTS OF A PILOT-STUDY

PSYCHONEUROENDOCRINOLOGY

卷:20

Article

TRAUTMAN, PD ; MEYERBAHLBURG, HFL ; POSTELNEK, J ; NEW, MI

关键词: CONGENITAL ADRENAL HYPERPLASIA (CAH);    DEXAMETHASONE (DEX);    CHILDREN;    BEHAVIOR;    DEVELOPMENT;    TEMPERAMENT;   

DOI  :  10.1016/0306-4530(94)00070-0

来源: Elsevier

【 摘 要 】

The effect of early prenatal dexamethasone (DEX) exposure on cognitive and behavioral development, behavior problems, and temperament were examined in 26 consecutively identified children aged 6 mo to 5 1/2 years, whose mothers had been DEX-treated during pregnancy because their offspring was at risk for congenital adrenal hyperplasia (CAH), and compared with 14 children from untreated CAH-risk pregnancies. Three children in each group were CAH-affected. Assessments were performed by way of mother-completed standard questionnaires. No significant differences in cognitive abilities or behavior problems were identified. On temperament questionnaires, DEX-exposed children showed more Shyness (p < .004), greater Emotionality (p < .03), less Sociability (p < .04), and a trend for greater Avoidance (p < .07) than unexposed children. DEX-exposed children also had significantly higher Internalizing (p < .002) and Total Problem scores (p < .05) on the behavior problem measure for 2-3 year olds. The results should be considered preliminary until they have been replicated by the study of a larger sample and direct examination of the children.

【 授权许可】

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