Sex-differentiated changes in C-reactive protein from ages 9 to 21: The contributions of BMI and physical/sexual maturation

PSYCHONEUROENDOCRINOLOGY

卷:38

Article

Shanahan, Lilly¹  Copeland, William E.²  Worthman, Carol M.³  Erkanli, Alaattin²  Angold, Adrian²  Costello, E. Jane² 

[1] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA

[2] Duke Univ, Med Ctr, Dev Epidemiol Program, Durham, NC 27706 USA

[3] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA

关键词: C-reactive protein;    Sex differences;    BMI;    Adolescence;    Young adulthood;    Puberty;    Testosterone;   

DOI  :  10.1016/j.psyneuen.2013.04.010

来源: Elsevier

【 摘 要 】

Background: Sex differences in levels of C-reactive protein (CRP) are well established in adulthood, but little is known about when and why they emerge. Here, we tested longitudinal models of CRP levels from ages 9 to 21, when marked physical and behavioral changes could contribute to growing sex disparities in CRP. Methods: Data from the community-based prospective-longitudinal Great Smoky Mountains Study (N = 1420) were used. Participants were 9-13 years old at intake and were followed through age 21. High-sensitivity C-reactive protein (CRP) was assayed from up to nine bloodspot collections per person. BMI, physical/sexual maturation, substance use, and control variables were assessed during yearly interviews to age 16, and at ages 19 and 21. Results: Multilevel models revealed that the development of CRP in females was best described by a quadratic trend: after slow increases in CRP until age 15, the rate of increase accelerated thereafter. Changes in CRP in males were best described by a smaller, linear increase. After sex-differentiated associations with BMI, physical/sexual maturation, and substance use variables had been accounted for, increases in CRP after age 15 no longer differed by sex. Conclusion: Physical/sexual maturation and behavioral changes during adolescence could initiate life-long sex disparities in CRP. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free