Volatility as a Concept to Understand the Impact of Stress on the Microbiome

PSYCHONEUROENDOCRINOLOGY

卷:124

Article

Bastiaanssen, Thomaz F. S.^1,2  Gururajan, Anand^1,2  van de Wouw, Marcel^1,2  Moloney, Gerard M.¹  Ritz, Nathaniel L.^1,2  Long-Smith, Caitriona M.^1,2  Wiley, Niamh C.³  Murphy, Amy B.^3,4  Lyte, Joshua M.¹  Fouhy, Fiona^2,3  Stanton, Catherine^2,3  Claesson, Marcus J.^2,4  Dinan, Timothy G.^2,5  Cryan, John F.^1,2 

[1] Univ Coll Cork, Dept Anat & Neurosci, Western Rd, Cork, Ireland

[2] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland

[3] TEAGASC, Food Res Ctr, Moorepk, Cork, Ireland

[4] Univ Coll Cork, Sch Microbiol, Cork, Ireland

[5] Univ Coll Cork, Dept Psychiat & Neurobehav Sci, Cork, Ireland

关键词: Chronic stress;    Microbiome;    Gut-brain axis;    Volatility;    Corticosterone;   

DOI  :  10.1016/j.psyneuen.2020.105047

来源: Elsevier

【 摘 要 】

The microbiome-gut-brain-axis is a complex phenomenon spanning several dynamic systems in the body which can be parsed at a molecular, cellular, physiological and ecological level. A growing body of evidence indicates that this axis is particularly sensitive to the effects of stress and that it may be relevant to stress resilience and susceptibility. Although stress-induced changes in the composition of the microbiome have been reported, the degree of compositional change over time, which we define as volatility, has not been the subject of in-depth scrutiny. Using a chronic psychosocial stress paradigm in male mice, we report that the volatility of the microbiome significantly correlated with several readouts of the stress response, including behaviour and corticosterone response. We then validated these findings in a second independent group of stressed mice. Additionally, we assessed the relationship between volatility and stress parameters in a cohort of health volunteers who were undergoing academic exams and report similar observations. Finally, we found inter-species similarities in the microbiome stress response on a functional level. Our research highlights the effects of stress on the dynamic microbiome and underscores the informative value of volatility as a parameter that should be considered in all future analyses of the microbiome.

【 授权许可】

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