Cognitive-behavioral stress management buffers decreases in dehydroepiandrosterone sulfate (DHEA-S) and increases in the cortisol/DHEA-S ratio and reduces mood disturbance and perceived stress among HIV-seropositive men

PSYCHONEUROENDOCRINOLOGY

卷:24

Article

Cruess, DG ; Antoni, MH ; Kumar, M ; Ironson, G ; McCabe, P ; Fernandez, JB ; Fletcher, M ; Schneider, N

关键词: DHEA-S;    cortisol/DHEA-S ratio;    CBSM;    HIV;    mood;    perceived stress;   

DOI  :  10.1016/S0306-4530(99)00010-4

来源: Elsevier

【 摘 要 】

This study examined the effects of a 10-week cognitive-behavioral stress management (CBSM) intervention on dehydroepiandrosterone sulfate (DHEA-S) levels and the ratio of cortisol to DHEA-S (cortisol/DHEA-S), potential surrogate adrenal markers of HIV disease progression, in relation to alterations in mood and distress. HIV-seropositive men were randomized to either a group-based CBSM intervention (n = 43) or to a wait-list control group (n = 24), with both hormonal and distress measures assessed just prior to and immediately following the 10-week period. Results showed that CBSM buffers decreases in DHEA-S and increases in the cortisol/DHEA-S ratio. Further examination also revealed that changes in the cortisol/DHEA-S ratio were significantly and positively related to changes in total mood disturbance and perceived stress over time. These findings demonstrate that a short-term CBSM intervention can buffer against decrements in DHEA-S and increments in the cortisol/DHEA-S ratio among symptomatic, HIV-positive men, and that alterations in the cortisol/DHEA-S ratio move in concert with changes in mood and distress observed during CBSM. (C) 1999 Elsevier Science Ltd. All rights reserved.

【 授权许可】

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