Serum DHEA-S Level Is Associated with the Presence of Atherosclerosis in Postmenopausal Women with Type 2 Diabetes Mellitus

Endocrine Journal

Soichi KURIOKA¹  Mika YAMAUCHI¹  Shozo YANO¹  Ippei KANAZAWA¹  Toshitsugu SUGIMOTO¹  Masahiro YAMAMOTO¹  Toru YAMAGUCHI¹ 

[1] Department of Internal Medicine 1, Shimane University Faculty of Medicine

关键词: DHEA-S;    IGF-I;    Type 2 diabetes mellitus;    Atherosclerosis;    Postmenopausal women;   

DOI  :  10.1507/endocrj.K07E-130

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(46)Cited-By(14)We investigated the relationship between serum dehydroepiandrosterone-sulfate (DHEA-S) and insulin-like growth factor-I (IGF-I) to various parameters for atherosclerosis in type 2 diabetes. The levels of DHEA-S and IGF-I are known to decrease with aging and thereby might be associated with an increased risk of cardiovascular disease. One hundred forty-eight men and 106 postmenopausal women with type 2 diabetes were assessed in a cross-sectional study. Serum DHEA-S and IGF-I concentrations were measured and brachial-ankle pulse wave velocity (baPWV) and ultrasonographically-evaluated intima-media thickness (IMT) were assessed. Although simple regression analysis showed that log(DHEA-S) and IGF-I in men and log(DHEA-S) in women were significantly and inversely correlated with baPWV and IMT, only log(DHEA-S) in women was still significantly and inversely correlated with these atherosclerotic parameters after multiple regression analysis was adjusted for age, duration of diabetes, BMI, HbA1C, systolic blood pressure, LDL-Cholesterol (C), serum creatinine, and smoking (Brinkman index). Serum DHEA-S level seemed to be associated with atherosclerosis in diabetic postmenopausal women independent of age, body stature, diabetic status, and other atherosclerotic risk factors, and might be a useful addition to other parameters for assessing the risk of atherosclerosis in this population.

【 授权许可】

Unknown