Diurnal coupling between testosterone and cortisol from adolescence to older adulthood

PSYCHONEUROENDOCRINOLOGY

卷:73

Article

Harden, K. Paige^1,2  Wrzus, Cornelia³  Luong, Gloria⁴  Grotzinger, Andrew¹  Bajbouj, Malek⁵  Rauers, Antje⁶  Wagner, Gert G.^7,8  Riediger, Michaela^6,8 

[1] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[2] Univ Texas Austin, Populat Res Ctr, Austin, TX 78712 USA

[3] Johannes Gutenberg Univ Mainz, Inst Psychol, Mainz, Germany

[4] Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA

[5] Charite, Clin Psychiat & Psychotherapy, Berlin, Germany

[6] Freie Univ, Heisenberg Res Grp Socioemot Dev & Hlth Lifespan, Berlin, Germany

[7] German Inst Econ Res, Berlin, Germany

[8] Max Planck Inst Human Dev, Berlin, Germany

关键词: Cortiso;    Testosterone;    Dual axis;    Coupling;    Hierarchical linear modeling;    Lifespan;   

DOI  :  10.1016/j.psyneuen.2016.07.216

来源: Elsevier

【 摘 要 】

The hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes are typically conceptualized as mutually inhibitory systems; however, previous studies have found evidence for positive within-person associations (i.e., coupling) between cortisol and testosterone. One developmental hypothesis is that positive testosterone-cortisol coupling is unique to the adolescent period and that coupling becomes attenuated, or even switches direction, in adulthood. This study used a lifespan sample (N = 292, ages 11-88) to test for age-related differences in coupling between cortisol and testosterone in daily life. Participants provided salivary hormone samples at waking, 30 min after waking, and during the evening for two days. Hierarchical linear modeling was used to test the within-person and between-person associations between testosterone and cortisol. Within-person associations were further decomposed into associations due to coupled diurnal change versus coupled variability around diurnal change. Results indicated positive associations between cortisol and testosterone at all levels of analysis. Additionally, positive coupling was evident across the lifespan, even in older adults who are no longer expected to reproduce, but further investigatiOn of developmental differences with a larger sample is necessary. Potential mechanisms and functions for positive coupling are discussed. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free