Pulsatile luteinizing hormone disruption in depression

PSYCHONEUROENDOCRINOLOGY

卷:29

Article

Grambsch, P ; Young, EA ; Meller, WH

关键词: hypothalamic-pituitary-ovarian;    axis;    spectral analysis;    periodogram;   

DOI  :  10.1016/S0306-4530(03)00146-X

来源: Elsevier

【 摘 要 】

Two independent groups recently published data comparing pulsatile luteinizing hormone (LH) release between depressed and control women. Despite similar populations and LH sampling frequency, they reached different conclusions: Meller et al. [Am. J. Psych. 154 (1997) 1454] found disruption of normal LH pulsatility in depressed women, whereas Young et al. [Arch. Gen. Psych. 57 (2000) 1157] did not. To resolve this discrepancy, the current study applies a single, well-established statistical method, spectral analysis, to the two data sets and concludes that both depressed populations display significantly altered LH pulsatile release. (C) 2003 Elsevier Ltd. All rights reserved.

【 授权许可】

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