Salivary biomarkers of stress and inflammation in first graders in Cote d′Ivoire: Effects of a probiotic food intervention

PSYCHONEUROENDOCRINOLOGY

卷:129

Article

Brett, Bonnie E.¹  Koko, Bruno K.²  Doumbia, Habib O. Y.²  Koffi, Frederic Kouadio²  Assa, Savorgnan E.²  Zahe, Kollet Y. A. S.²  Faye-Kette, Hortense^2,3  Kati-Coulibaly, Seraphin^2,3  Kort, Remco^4,5  Sybesma, Wilbert⁴  Reid, Gregor⁶  de Weerth, Carolina¹ 

[1] Radboud Univ Nijmegen, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, Med Ctr, POB 9010, NL-6500 GL Nijmegen, Netherlands

[2] Univ Felix Houghouet Baigny, UFR Biosci, Abidjan BP V34, Cote Ivoire

[3] CHU, Inst Pasteur Cote Ivoire, Abidjan, Cote Ivoire

[4] Yoba Life Fdn, Hunzestr 133-A, NL-1079 WB Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Dept Mol Cell Biol, Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands

[6] Western Univ, Lawson Hlth Res Inst, 268 Grosvenor St, London, ON N6A 4V2, Canada

关键词: Cortisol;    C-reactive protein;    Probiotic;    Food supplement;    Inflammation;    Stress;   

DOI  :  10.1016/j.psyneuen.2021.105255

来源: Elsevier

【 摘 要 】

This semi-randomized controlled trial examined the effects of a probiotic food supplement on cortisol and Creactive protein (CRP) in a sample of 262 four-to seven-year-old children (56% girls) in two economicallydisadvantaged schools in an urban setting in Co circle te d ' Ivoire. For one semester, children in one school were randomized to receive a probiotic (N = 79) or placebo (N = 85) fermented dairy food each day they attended school; one child (due to medical reasons) and all children in the other school (N = 98) continued their diets as usual. Children provided two saliva samples at 11:30 on consecutive days at the end of the study. Analyses revealed that the probiotic group had lower cortisol than the placebo or diet-as-usual groups (p = .015); CRP levels were comparable across groups (p = .549). Exploratory analyses suggested that dose and regularity of consumption may impact the biomarkers as well. This study provides the first evidence that a probiotic milk product may lower cortisol in a sample of young, economically-disadvantaged children.

【 授权许可】

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