Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:368

Review

Nagy, Zsuzsanna S.¹  Czimmerer, Zsolt¹  Nagy, Laszlo^1,2 

[1] Univ Debrecen Med & Hlth Sci Ctr, Res Ctr Mol Med, Dept Biochem & Mol Biol, H-4032 Debrecen, Hungary

[2] Univ Debrecen Med & Hlth Sci Ctr, Hungarian Acad Sci, Stem Cell Apoptosis & Genom Res Grp, H-4032 Debrecen, Hungary

关键词: Macrophage;    Nuclear receptor;    Cholesterol;    Metabolism;    Transcriptional regulation;   

DOI  :  10.1016/j.mce.2012.04.003

来源: Elsevier

【 摘 要 】

Macrophages comprise a family of multi-faceted phagocytic effector cells that differentiate in situ from circulating monocytes to exert various functions including clearance of foreign pathogens as well as debris derived from host cells. Macrophages also possess the ability to engulf and metabolize lipids and this way connect lipid metabolism and inflammation. The molecular link between these processes is provided by certain members of the nuclear receptor family. For instance, peroxisome proliferator activated receptors (PPAR) and liver X receptors (LXR) are able to sense the dynamically changing lipid environment and translate it to gene expression changes in order to modulate the cellular phenotype. Atherosclerosis embodies both sides of this coin: it is a disease in which macrophages with altered cholesterol metabolism keep the arteries in a chronically inflamed state. A large body of publications has accumulated during the past few decades describing the role of nuclear receptors in the regulation of macrophage cholesterol homeostasis, their contribution to the formation of atherosclerotic plagues and their crosstalk with inflammatory pathways. This review will summarize the most recent findings from this field narrowly focusing on the contribution of various nuclear receptors to macrophage cholesterol metabolism. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free