Impact of G protein-coupled receptor heteromers in endocrine systems

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:449

Article

Jonas, K. C.¹  Hanyaloglu, A. C.² 

[1] St Georges Univ London, Ctr Med & Biomed Educ, Cell Biol & Genet Res Ctr, London, England

[2] Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Cancet, London, England

关键词: GPCR;    Dimer;    Oligomer;    Signaling;    Heteromer;   

DOI  :  10.1016/j.mce.2017.01.030

来源: Elsevier

【 摘 要 】

The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine heath and disease. Crown Copyright (C) 2017 Published by Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free