Microparticles: Inflammatory and haemostatic biomarkers in Polycystic Ovary Syndrome

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:443

Article

Carvalho, L. M. L.¹  Ferreira, C. N.²  Soter, M. O.³  Sales, M. F.¹  Rodrigues, K. F.¹  Martins, S. R.³  Candido, A. L.⁴  Reis, F. M.⁴  Silva, I. F. O.³  Campos, F. M. F.³  Gomes, K. B.^1,3,5 

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Col Tecnico, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Farm, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Dept Clin & Toxicol Anal, Fac Pharm, Avenida Antonio Carlos,6627 Pampulha, BR-31270901 Belo Horizonte, MG, Brazil

关键词: Polycystic Ovary Syndrome;    Microparticles;    Platelets;    Leukocytes;    Endothelial cells;    Tissue factor;   

DOI  :  10.1016/j.mce.2017.01.017

来源: Elsevier

【 摘 要 】

Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the micro particles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

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