Tissue concentrations of estrogens and aromatase immunolocalization in interstitial pneumonia of human lung

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:392

Article

Miki, Yasuhiro^2,3  Abe, Keiko⁴  Nakamura, Yasuhiro²  Fue, Misaki³  Ishida, Kazuyuki⁵  Sakakibara, Tomohiro⁶  Maeda, Sumiko⁷  Suzuki, Takashi^1,8  Sasano, Hironobu² 

[1] Tohoku Univ, Grad Sch Med, Dept Pathol, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Anat Pathol, Sendai, Miyagi 9808575, Japan

[3] Tohoku Univ, Int Res Inst Disaster Sci, Dept Disaster Obstet & Gynecol, Sendai, Miyagi 9808575, Japan

[4] Saitama Med Univ, Saitama Med Ctr, Dept Pathol, Saitama, Japan

[5] Iwate Med Univ, Sch Med, Dept Pathol, Div Diagnost Mol Pathol, Morioka, Iwate, Japan

[6] Tohoku Univ, Grad Sch Med, Dept Resp Med, Sendai, Miyagi 9808575, Japan

[7] Tohoku Univ Hosp, Dept Thorac Surg, Sendai, Miyagi, Japan

[8] Tohoku Univ, Grad Sch Med, Dept Histotechnol, Sendai, Miyagi 9808575, Japan

关键词: Aromatase;    Estrogen;    Interstitial pneumonia;    Lung;   

DOI  :  10.1016/j.mce.2014.05.016

来源: Elsevier

【 摘 要 】

Interstitial pneumonia (IP) is characterized by various degrees of pulmonary fibrosis and inflammation. Estrogens have been demonstrated to play important roles in physiological and pathological conditions of human lung, but significance of estrogens has remained unknown in human IF. Therefore, we measured estrogen concentrations and immunolocalized aromatase and estrogen receptor beta (ER beta) in IP tissues. Estradiol concentration was significantly (2.8-fold) higher in IP than normal lung tissues, and aromatase activity evaluated by estradiol/testosterone ratio was also significantly (7.2-fold) elevated in IP tissues. Aromatase immunoreactivity in alveolar epithelial cells was significantly frequent in IP than normal lung or inflammatory lung disease other than IP, and it was positively associated with ER beta immunoreactivity in these cells of IP. These results suggest that estradiol concentration is locally increased in human IP tissue by aromatase, and increased estrogens may play an important role in the development of IP through ER beta in the alveolar epithelial cells. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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