MicroRNAs in pituitary tumors

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:456

Article

Wierinckx, Anne^1,2,3,4,5  Roche, Magali⁶  Legras-Lachuer, Catherine^1,5,6,7  Trouillas, Jacqueline^1,8  Raverot, Gerald^1,3,4,9  Lachuer, Joel^1,2,3,4,5 

[1] Univ Lyon 1, Lyon, France

[2] Univ Lyon, Inst Univ Technol Lyon1, F-69622 Villeurbanne, France

[3] Canc Res Ctr Lyon, INSERM, U1052, F-69373 Lyon 08, France

[4] Canc Res Ctr Lyon, CNRS, UMR 5286, F-69373 Lyon 08, France

[5] ProfileXpert, SFR Est, CNRS, UMR S3453,INSERM,US7, F-69373 Lyon 08, France

[6] ViroScan3D, F-01600 Trevoux, France

[7] ENVL, Dynam Microbienne & Transmiss, INRA, CNRS,UMR 5557,UCBL,USC 1193, F-69100 Villeurbanne, France

[8] Hosp Civils Lyon, Grp Hosp Est, Ctr Pathol Est, F-69677 Bron, France

[9] Hosp Civils Lyon, Grp Hosp Est, Federat Endocrinol, F-69677 Bron, France

关键词: microRNAs;    Pituitary tumors;   

DOI  :  10.1016/j.mce.2017.01.021

来源: Elsevier

【 摘 要 】

Since the presence of microRNAs was first observed in normal pituitary, the majority of scientific publications addressing their role and the function of microRNAs in the pituitary have been based on pituitary tumor studies. In this review, we briefly describe the involvement of microRNAs in the synthesis of pituitary hormones and we present a comprehensive inventory of microRNA suppressors and inducers of pituitary tumors. Finally, we summarize the functional role of microRNAs in tumorigenesis, progression and aggressiveness of pituitary tumors, mechanisms contributing to the regulation (transcription factors, genomic modifications or epigenetic) or modulation (pharmacological treatment) of microRNAs in these tumors, and the interest of thoroughly studying the expression of miRNAs in body fluids. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

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