Epigenetic Control in Pituitary Tumors

Endocrine Journal

Shereen EZZAT¹ 

[1] Department of Medicine, University of Toronto

关键词: Pituitary tumors;    Epigenetic control;    MAGE;    FGFR2;   

DOI  :  10.1507/endocrj.K08E-082

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(55)Cited-By(11)Epigenetically-mediated gene dysregulation is a common feature associated with human pituitary tumorigenesis. The mechanisms leading to these changes, however, remain largely unknown. In this review, we examine changes responsible for DNA and histone modifications as independent, butpotentially interrlated modes of communication effecting chromatin remodeling. The dynamic properties of the enzymes involved in these reactions is highlighted. We use the fibroblast growth factor receptor 2 (FGFR2) as a model through which the p53-regulating melanoma-associated antigen (MAGE) system is governing in pituitary cells. The pathogenetic and potential therapeutic implications are discussed.

【 授权许可】

Unknown