Bisphenol A: Perinatal exposure and body weight

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:304

Article; Proceedings Paper

Rubin, Beverly S.¹  Soto, Ana M.¹ 

[1] Tufts Univ, Sch Med, Dept Anat & Cellular Biol, Boston, MA 02111 USA

关键词: Endocrine disruptors;    Obesity;    Perinatal exposure;    Fetal and neonatal exposure;    Xenoestrogens;    Body weight regulation;    Fetal basis of adult disease;   

DOI  :  10.1016/j.mce.2009.02.023

来源: Elsevier

【 摘 要 】

Bisphenol A (BPA) is a component of polycarbonate and other plastics including resins that line food and beverage containers. BPA is known to leach from products in contact with food and drink, and is therefore thought to be routinely ingested. In a recent cross sectional study, BPA was detected in urine samples from 92.6% of the US population examined. The potential for BPA to influence body weight is suggested by in vitro studies demonstrating effects of BPA on adipocyte differentiation, lipid accumulation, glucose transport and adiponectin secretion. Data from in vivo studies have revealed dose-dependent and sex dependent effects on body weight in rodents exposed perinatally to BPA. The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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