Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

PHYSIOLOGY & BEHAVIOR

卷:130

Article

Kohara, Yumi¹  Kuwahara, Rika²  Kawaguchi, Shinichiro²  Jojima, Takeshi¹  Yamashita, Kimihiro³ 

[1] Nagasaki Univ, Grad Sch Fisheries Sci & Environm Studies, Nagasaki 8528521, Japan

[2] Nagasaki Univ, Grad Sch Sci & Technol, Nagasaki 8528521, Japan

[3] Nagasaki Univ, Grad Sch Fisheries Sci & Environm Studies, Inst Environm Studies, Div Environm Chem & Ecotoxicol, Nagasaki 8528521, Japan

关键词: Genistein;    Isoflavone;    Central nervous system;    Perinatal exposure;    Behavior;    Non-monotonic dose response;   

DOI  :  10.1016/j.physbeh.2014.03.006

来源: Elsevier

【 摘 要 】

This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10 mg/kg/day) or vehicle (1 ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and step-through passive avoidance tests. MAZE test is an appetite-motivation test, and we used this mainly for assessing spatial learning and memory. In the MAZE test, GEN groups exhibited shorter latency from start to goal than the vehicle-treated group in both sexes. On the other hand, performances in the step-through passive avoidance test were non-monotonically inhibited by GEN in both sexes, and a significant difference was observed in low dose of the GEN-treated group compared to the vehicle-treated group in female rats. Furthermore, we found that perinatal exposure to GEN did not significantly alter locomotor activity or emotionality as assessed by the open-field and elevated-plus maze tests. These results suggest that perinatal exposure to GEN improved spatial learning and memory drat offspring, but impaired their passive avoidance learning and memory. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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