Association of serum leptin with future left ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis (MESA)

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:193

Article

Sharma, Shishir¹  Colangelo, Laura A.¹  Allison, Matthew A.²  Lima, Joao A. C.³  Ambale-Venkatesh, Bharath³  Kishi, Satoru³  Liu, Kiang¹  Greenland, Philip¹ 

[1] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Univ Calif San Diego, San Diego, CA 92103 USA

[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

关键词: Leptin;    Adipokine;    Cardiac structure;    Left ventricular mass;   

DOI  :  10.1016/j.ijcard.2015.05.068

来源: Elsevier

【 摘 要 】

Background/objectives: Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. Methods: MESA is amulticenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. Results: Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m(2)), LV end diastolic volume index (LVEDVi) (-7 ml/m(2)), LV end systolic volume index (LVESVi) (-3 ml/m(2)) and stroke volume (-5 ml) (all p = 0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g +/- 0.7 g), LV mass index (-1.7 +/- 0.3 g/m(2)), LVEDVi (-1.5 +/- 0.4 ml/m(2)), LVESVi (-0.7 +/- 0.2 ml/m(2)) and stroke volume (-1.0 +/- 0.5 ml) (all p = 0.05). Conclusions: Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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