Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: Preliminary findings

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:221

Article

Campo, Gianluca^1,2  Morciano, Giampaolo^2,3  Pavasini, Rita¹  Bonora, Massimo^2,3  Sbano, Luigi^2,3  Biscaglia, Simone¹  Bovolenta, Matteo⁴  Pinotti, Mirko⁴  Punzetti, Silvia¹  Rizzo, Paola⁵  Aquila, Giorgio⁵  Giorgi, Carlotta^2,3  Ferrari, Roberto^1,2,6  Pinton, Paolo^2,3 

[1] Azienda Osped Univ S Anna, Cardiovasc Inst, Via A Moro 8, Cona, FE, Italy

[2] Univ Ferrara, Lab Technol Adv Therapies LTTA, Ferrara, Italy

[3] Univ Ferrara, Sect Pathol Oncol & Expt Biol, Dept Morphol Surg & Expt Med, Ferrara, Italy

[4] Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy

[5] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[6] ES Hlth Sci Fdn, GVM Care & Res, Maria Cecilia Hosp, Cotignola, Italy

关键词: ST-segment elevation MI;    Reperfusion injury;    Mitochondrial permeability transition pore;    F1Fo ATP synthase C subunit;    Infarct size;    ST-segment resolution;   

DOI  :  10.1016/j.ijcard.2016.07.125

来源: Elsevier

【 摘 要 】

Background: Recent studies in cell cultures hypothesized that the long-sought molecular pore of the mitochondrial permeability transition pore could be the Fo ATP synthase C subunit (Csub). We assessed Csub in patients with ST-segment elevation myocardial infarction (STEMI) and if it is associated with surrogate endpoints of myocardial reperfusion. Methods: We enrolled 158 first-time acute anterior STEMI treated with successful percutaneous coronary intervention (PCI). Csub was measured, after the procedure, in serum by ELISA. Csub values were related to thrombolysis in myocardial infarction (TIMI) myocardial perfusion grade (TMPG), TIMI frame count (TFC), ST-segment resolution and cardiac marker release. Echocardiography and clinical outcome were recorded at 6 months. Results: Csub was detectable in serum and it was not normally distributed (6.3% [4-9.3%]). Csub values were higher in patients with poor values of TMPG and TFC (p = 0.002 and p = 0.001, respectively). Csub values were higher in patients with absent or partial ST-segment resolution as compared to those with complete ST-segment resolution (p < 0.0001 and p = 0.003, respectively). After adjustment for potential confounding factors, Csub emerged as an independent determinant of absent ST-segment resolution (HR 1.8, 95% CI 1.5-2.3, p = 0.007), TMPG 0-1 (HR 1.7, 95% CI 1.3-2.5, p = 0.01) and TFC above the median value (HR 1.5, 95% CI 1.3-2.1, p = 0.03). Left ventricle ejection fraction, wall motion score index and cumulative incidence of death and heart failure were worse in patients with elevated Csub. Conclusions: Our study is the first evidence that Csub is detectable in STEMI patients and that it is significantly related to several surrogate markers of myocardial reperfusion. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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