Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:268

Article

Orrem, Hilde L.^1,2,3  Shetelig, Christian^3,4,5  Ueland, Thor^3,6,7  Limalanathan, Shanmuganathan^4,5,8  Nilsson, Per H.^9,10  Husebye, Trygve^4,11  Aukrust, Pal^3,6,9,12  Seljeflot, Ingebjorg^3,4,5,11  Hoffmann, Pavel^3,13  Eritsland, Jan^4,5  Mollnes, Tom E.^1,7,9,14,15  Andersen, Geir Oystein^4,5,11  Yndestad, Arne^3,6,9,11 

[1] Oslo Univ Hosp, Dept Immunol, Rikshosp, Oslo, Norway

[2] Oslo Univ Hosp, Dept Anesthesiol, Rikshosp, Oslo, Norway

[3] Univ Oslo, Inst Clin Med, Oslo, Norway

[4] Oslo Univ Hosp Ulleval, Dept Cardiol, Oslo, Norway

[5] Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Oslo, Norway

[6] Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Oslo, Norway

[7] Univ Tromso, KG Jebsen TREC, Tromso, Norway

[8] Feiring Heart Clin, Feiring, Norway

[9] Univ Oslo, KG Jebsen Inflammatory Res Ctr, Oslo, Norway

[10] Linnaeus Univ, Linnaeus Ctr Biomat Chem, Kalmar, Sweden

[11] Univ Oslo, Ctr Heart Failure Res, Oslo, Norway

[12] Oslo Univ Hosp, Sect Clin Immunol & Infect Dis, Rikshosp, Oslo, Norway

[13] Oslo Univ Hosp Ulleval, Sect Intervent Cardiol, Oslo, Norway

[14] Nordland Hosp, Res Lab, Bodo, Norway

[15] Norwegian Univ Sci, Ctr Mol Inflammat Res, Trondheim, Norway

关键词: Inflammation;    Cytokine;    Interleukin-1;    Acute coronary syndromes;    Myocardial infarction;    Ventricular remodelling;   

DOI  :  10.1016/j.ijcard.2018.05.032

来源: Elsevier

【 摘 要 】

Background: The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1 alpha and IL-1 beta are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling. Methods: Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n=65). Results: IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates. Conclusion: Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI. (C 18 Elsevier B.V. All rights reserved.

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