Topical calcineurin inhibitors for pediatric periorificial dermatitis

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:82

Article

Ollech, Ayelet¹  Yousif, Rame²  Kruse, Lacey^1,2,3  Wagner, Annette^1,2,3  Kenner-Bell, Brandi^1,2,3  Chamlin, Sarah^1,2,3  Yun, Duri^1,2,3  Shen, Lisa⁴  Vivar, Karina^1,2,3  Reynolds, Megan¹  Paller, Amy S.^1,2,3  Mancini, Anthony J.^1,2,3 

[1] Ann & Robert H Lurie Childrens Hosp Chicago, Div Dermatol, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Pediat, Chicago, IL 60611 USA

[4] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02215 USA

关键词: azithromycin;    erythromycin;    minocycline;    pediatric dermatology;    perioral dermatitis;    periorificial dermatitis;    pimecrolimus;    tacrolimus;    topical calcineurin inhibitor;    topical metronidazole;   

DOI  :  10.1016/j.jaad.2020.01.064

来源: Elsevier

【 摘 要 】

Background: Data regarding the treatment of periorificial dermatitis with topical calcineurin inhibitors (TCI) in the pediatric population are limited. Objective: To assess the clinical utility of TCI in pediatric patients with periorificial dermatitis. Methods: A retrospective medical record review of all pediatric patients with periorificial dermatitis treated with TCIs was performed. Follow-up via telephone was performed to capture missing data. Results: A total of 132 patients met the inclusion criteria. The median age at diagnosis was 4.2 years (interquartile range, 2.3-8.2). The median follow-up was 5.2 months (interquartile range, 2.1-11.7). Seventy-two patients had evaluable follow-up data. Of these, 48 (67%) patients were treated with TCI alone, 12 (16.7%) were treated with a combination of TCI and topical metronidazole, and 9 (12.5%) were treated with a combination of TCI and a systemic antibiotic. Complete response was noted in 68.8% of patients treated with TCI alone, in 75% of patients treated with TCI and metronidazole, and in 77.8% of patients treated with TCI and a systemic antibiotic. Adverse events were rare and mild in severity. Conclusion: Topical calcineurin inhibitors are an effective therapeutic option for pediatric patients with periorificial dermatitis and were well tolerated in this cohort.

【 授权许可】

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