Macrolide Allergic Reactions

Pharmacy

卷:7

JonathanC. Cho¹  Sheeba Varghese Gupta²  KristyM. Shaeer³  EliasB. Chahine⁴ 

[1] Department of Clinical Sciences, Ben and Maytee Fisch College of Pharmacy, University of Texas at Tyler, Tyler, TX 75799, USA;

[2] Department of Pharmaceutical Sciences, University of South Florida College of Pharmacy, Tampa, FL 33612, USA;

[3] Department of Pharmacotherapeutics and Clinical Research, University of South Florida College of Pharmacy, Tampa, FL 33612, USA;

[4] Department of Pharmacy Practice, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL 33416, USA;

关键词: macrolides;    allergy;    azithromycin;    erythromycin;    clarithromycin;    fidaxomicin;    desensitization;   

DOI  :  10.3390/pharmacy7030135

来源: DOAJ

【 摘 要 】

Macrolides are antimicrobial agents that can be used to treat a variety of infections. Allergic reactions to macrolides occur infrequently but can include minor to severe cutaneous reactions as well as systemic life-threatening reactions such as anaphylaxis. Most reports of allergic reactions occurred in patients without prior exposure to a macrolide. Cross-reactivity among macrolides may occur due to the similarities in their chemical structures; however, some published literature indicates that some patients can tolerate a different macrolide. Most published reports detailed an allergic reaction to erythromycin. Desensitization protocols to clarithromycin and azithromycin have been described in the literature. The purpose of this article is to summarize macrolide-associated allergic reactions reported in published literature. An extensive literature search was conducted to identify publications linking macrolides to hypersensitivity reactions.

【 授权许可】

Unknown