The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:77

Article

Kohli, Indermeet¹  Shafi, Rubina²  Isedeh, Prescilia¹  Griffith, James L.¹  Al-Jamal, Mohammed S.¹  Silpa-archa, Narumol¹  Jackson, Bradford²  Athar, Mohammed²  Elmets, Craig A.²  Lim, Henry W.¹  Hamzavi, Iltefat H.¹ 

[1] Henry Ford Hosp, Dept Dermatol, Multicultural Dermatol Ctr, New Ctr One,3031 W Grand Blvd,Suite 800, Detroit, MI 48202 USA

[2] Univ Alabama Birmingham, Dept Dermatol, Birmingham, AL USA

关键词: colorimetry;    cyclobutane pyrimidine dimers;    excimer laser;    minimal erythema dose;    Polypodium leucotomos extract;    sunburn cells;    ultraviolet;   

DOI  :  10.1016/j.jaad.2017.01.044

来源: Elsevier

【 摘 要 】

Background: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE. Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects. Limitations: Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied. Conclusion: The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.

【 授权许可】

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