Clinical and dermoscopic characteristics of congenital and noncongenital nevus-associated melanomas

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:83

Article

Zalaudek, Iris¹  Conforti, Claudio¹  Guarneri, Fabrizio²  Vezzoni, Roberta¹  Deinlein, Teresa³  Hofmann-Wellenhof, Rainer³  Longo, Caterina^4,5  Moscarella, Elvira⁶  Kittler, Harald⁷  Argenziano, Giuseppe⁶  Giuffrida, Roberta² 

[1] Univ Trieste, Dept Dermatol & Venereol, Osped Maggiore, Trieste, Italy

[2] Univ Messina, Dept Clin & Expt Med, Sect Dermatol, Messina, Italy

[3] Med Univ Graz, Dept Dermatol & Venereol, Graz, Austria

[4] Univ Modena & Reggio Emilia, Dept Dermatol, Modena, Italy

[5] Ist Ricovero & Cura Carattere Sci IRCCS Reggio Em, Ctr Oncol Alta Tecnol Diagnost, Azienda Unita Sanit Locale, Reggio Emilia, Italy

[6] Univ Campania Luigi Vanvitelli, Dermatol Unit, Naples, Italy

[7] Med Univ Vienna, Dept Dermatol, Vienna, Austria

关键词: dermoscopy;    melanoma;    nevogenesis;    nevus;    nevus-associated melanoma;    skin cancer;   

DOI  :  10.1016/j.jaad.2020.04.120

来源: Elsevier

【 摘 要 】

Background: No specific features of nevus-associated melanoma (NAM) are currently defined. Objective: To identify clinical/dermoscopic features of NAM. Methods: Retrospective evaluation of histopathologically diagnosed NAM. Results: Eighty of 165 NAMs had a clinically recognizable nevus component, often raised or nodular, most frequently characterized by different morphologic clones and/or colors. In 111 of 165 NAMs, dermoscopy showed a nevus component, prevalently characterized by regular dots/clods and structureless brown areas. Clinically, the melanoma component was eccentric/peripheral in 45 of 80 cases and central in 35 of 80; dermoscopically, the figures were 59 of 111 and 52 of 111, respectively. Melanomas associated with congenital nevi (C-NAMs) occur at a younger age and have a thicker Breslow depth than melanomas associated with acquired nevi (NC-NAMs). Dermoscopically, regular dots/globules characterize C-NAMs, and hypopigmented structureless areas characterize NC-NAMs. Limitations: Retrospective analysis. Conclusion: C-NAMs are more often central to a congenital nevus, with a clod/globular or structureless brown pattern, typical of young patients. NC-NAMs are frequently hypopigmented nodules/plaques, eccentric/peripheral, with hypopigmented structureless areas, typical of older patients.

【 授权许可】

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