The study of nevi in children: Principles learned and implications for melanoma diagnosis

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:75

Article

Scope, Alon^1,4,5  Marchetti, Michael A.¹  Marghoob, Ashfaq A.¹  Dusza, Stephen W.¹  Geller, Alan C.⁶  Satagopan, Jaya M.^2,3  Weinstock, Martin A.^7,8,9,10,11  Berwick, Marianne¹²  Halpern, Allan C.¹ 

[1] Mem Sloan Kettering Canc Ctr, Dermatol Serv, 16 E 60th St, New York, NY 10022 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[4] Tel Aviv Univ, Sheba Med Ctr, Dept Dermatol, IL-69978 Tel Aviv, Israel

[5] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[6] Harvard Sch Publ Hlth Social & Behav Sci, Boston, MA USA

[7] Rhode Isl Hosp, Dermatoepidemiol Unit, Providence, RI USA

[8] Rhode Isl Hosp, Vet Affairs Med Ctr, Providence, RI USA

[9] Rhode Isl Hosp, Dept Dermatol, Providence, RI USA

[10] Brown Univ, Dept Dermatol, Providence, RI 02912 USA

[11] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA

[12] Univ New Mexico, Div Epidemiol & Biostat, Albuquerque, NM 87131 USA

关键词: adolescence;    childhood;    dermoscopy;    detection;    melanoma;    nevi;    nevogenesis;   

DOI  :  10.1016/j.jaad.2016.03.027

来源: Elsevier

【 摘 要 】

Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive understanding of the morphologic characteristics of nevi in different anatomic locations, in association with the patient's age and pigmentary phenotype may aid in the identification of melanomas. When monitoring melanocytic lesions over time, it is essential to differentiate normal from abnormal change. This review summarizes the rapidly expanding body of literature relevant to nevus phenotype, particularly in the context of our experience with the Study of Nevi in Children (SONIC) Project.

【 授权许可】

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