Tyrosine kinases in inflammatory dermatologic disease

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:65

Review

Paniagua, Ricardo T.^1,2  Fiorentino, David F.³  Chung, Lorinda^1,2  Robinson, William H.^1,2 

[1] Vet Affairs Hlth Care Syst, Palo Alto Dept, Geriatr Res Educ & Clin Ctr, Palo Alto, CA 94304 USA

[2] Stanford Univ, Dept Med, Sch Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Dermatol, Sch Med, Stanford, CA 94305 USA

关键词: autoimmune;    dermatology;    dermatomyositis;    fibrosis;    inflammatory;    pemphigus;    phosphorylation;    psoriasis;    tyrosine kinase;   

DOI  :  10.1016/j.jaad.2010.04.026

来源: Elsevier

【 摘 要 】

Tyrosine kinases (TKs) are enzymes that catalyze the phosphorylation of tyrosine residues on protein substrates. They are key components of signaling pathways that drive an array of cellular responses including proliferation, differentiation, migration, and survival. Specific TKs have recently been identified as critical to the pathogenesis of several autoimmune and inflammatory diseases. Small-molecule inhibitors of TKs are emerging as a novel class of therapy that may provide benefit in certain patient subsets. In this review, we highlight TK signaling implicated in inflammatory dermatologic diseases, evaluate strategies aimed at inhibiting these aberrant signaling pathways, and discuss prospects for future drug development. (J Am Acad Dermatol 2011;65:389-403.)

【 授权许可】

Free