Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:76

Review

Huang, Yu-Chen^1,2  Cheng, Ying-Chih^3,4,5 

[1] Taipei Med Univ, Wan Fang Hosp, Dept Dermatol, 111,Hsing Long Rd Sec 3, Taipei 116, Taiwan

[2] Taipei Med Univ, Sch Med & Coll Med, Dept Dermatol, Taipei, Taiwan

[3] Cardinal Tien Hosp, Dept Psychiat, New Taipei, Taiwan

[4] Natl Taiwan Univ, Coll Publ Hlth, Dept Publ Hlth, Taipei, Taiwan

[5] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan

关键词: acne;    depression;    isotretinoin;    meta-analysis;    psychological impact;    systemic review;   

DOI  :  10.1016/j.jaad.2016.12.028

来源: Elsevier

【 摘 要 】

Background: The relationship between isotretinoin treatment for acne and depression is controversial. Quantitative analysis has not yet been conducted. Objective: To conduct a meta-analysis, evidence-based examination of the relationship between isotretinoin and depression. Method: A systematic review and meta-analysis of the literature published from inception to September 30, 2016, was conducted. Controlled or prospectivenon-controlledtrialson >= 15 acnepatients receiving isotretinoin treatment were included. The prevalence of depression and change in depression scores were calculated. Result: Thirty-one studies met the inclusion criteria. In the controlled studies, the change in depression scores from baseline was not significantly different between patients receiving isotretinoin treatment and those receiving an alternative treatment (standardized mean difference [SMD] -0.334, 95% confidence interval [CI] -0.680 to 0.011). The prevalence of depression after isotretinoin treatment significantly declined (relative risk [RR] 0.588, 95% CI 0.382e0.904). The mean depression scores significantly decreased from baseline (SMD -0.335, 95% CI -0.498 to -0.172). Limitations: No randomized controlled trials were reviewed; a large inter-study variation was observed. Conclusions: Isotretinoin treatment for acne does not appear to be associated with an increased risk for depression. Moreover, the treatment of acne appears to ameliorate depressive symptoms.

【 授权许可】

Free