A Review of Systemic Retinoid Therapy for Acne and Related Conditions

Skin Therapy Letter-Family Practice Edition

关键词: acne;    isotretinoin;    retinoids Isotretinoin (13 cis-retinoic acid;    Accutane®;    Roaccutane®;    Roche Pharmaceuticals) is a naturally occurring substance which;    since its introduction in 1982;    has revolutionized acne therapy. It is the only anti-acne agent that affects all four of the known major etiologic mechanisms: sebum production;    comedogenesis;    Propionobacterium acnes (P. acnes) colonization of ductal and skin surface;    and monocyte chemotaxis-induced inflammation. This may explain its unique ability to sustain long term treatment-free remissions and;    in some cases;    a permanent remission or “cure” can be achieved.1;    2;   

DOI  :  

学科分类：医学（综合）

来源: Skin Therapy Letter-Family Practice Edition

【 摘 要 】

Oral isotretinoin, since its introduction more than 20 years ago, has been and still is the “ gold standard” in the treatment of acne and its variants. This is the only approach to acne with the possibility of a permanent “cure” or long term remission. The role of isotretinoin has evolved with higher dosage schedules and use earlier in the course of the disease. The frequency of laboratory monitoring has diminished along with associated costs based on 2 decades of experience. Pregnancy-associated safeguards have become a more prominent facet of oral retinoid therapy leading to increased safety for its use in females of childbearing potential.

【 授权许可】

Unknown