Calciphylaxis: Comparison of radiologic imaging and histopathology

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:77

Article

Halasz, Charles L.^1,2  Munger, David P.³  Frimmer, Heather³  Dicorato, Michael⁴  Wainwright, Sandra⁵ 

[1] Columbia Univ, Dept Dermatol, Med Ctr, New York, NY 10027 USA

[2] Norwalk Hosp, Dept Med, 149 East Ave,Suite 20, Norwalk, CT 06851 USA

[3] Norwalk Hosp, Dept Radiol, 149 East Ave,Suite 20, Norwalk, CT 06851 USA

[4] Norwalk Hosp, Dept Pathol, 149 East Ave,Suite 20, Norwalk, CT 06851 USA

[5] Greenwich Hosp, Dept Hyperbar Med, Greenwich, CT USA

关键词: calcific uremic arteriolopathy;    calciphylaxis;    mammography;    radiologic imaging;   

DOI  :  10.1016/j.jaad.2017.01.040

来源: Elsevier

【 摘 要 】

Background: The current gold standard for diagnosis of calciphylaxis is a skin biopsy specimen demonstrating calcification of small-caliber arteries or arterioles. Objective: The aim of this study is to compare diameters of calcified vessels seen in skin biopsy specimens and radiology images of patients with calciphylaxis. Methods: We conducted a retrospective study of patients with known calciphylaxis from 2009 to 2016 at a community hospital who had both skin biopsy specimens and radiology images taken as part of their routine care. Vascular calcification was compared in skin biopsy specimens and radiology images. Results: Seven patients were identified. Small-vessel calcification as fine as 0.1 to 0.3 mm was identified on plain films in 3 patients; 0.1 to 0.2 mm by mammography in 3 patients, and 0.1 to 0.2 mm by computed tomography imaging in 1 patient, nearly as fine a resolution as on histopathology. Limitations: This was a single-center study with limited sample size. Conclusion: Radiologic imaging might enable more rapid diagnosis of calciphylaxis when skin biopsy specimen is pending or not available.

【 授权许可】

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