Pretreatment Radiologically Enlarged Lymph Nodes as a Significant Prognostic Factor in Clinical Stage IIB Cervical Cancer: Evidence from a Taiwanese Tertiary Care Center in Reaching Consensus

Diagnostics

Peng-Hui Wang¹  Wei-Ting Chao¹  Na-Rong Lee¹  Chia-Hao Liu¹  Wen-Hsun Chang¹  Yi-Jen Chen¹  Szu-Ting Yang¹  Jeff Chien-Fu Lin² 

[1] Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan;Department of Statistics, National Taipei University, Taipei 112, Taiwan;

关键词: cervical cancer;    clinical stage IIB;    enlarged lymph nodes;    radiologic imaging;    progression-free survival;    overall survival;   

DOI  :  10.3390/diagnostics12051230

来源: DOAJ

【 摘 要 】

The incidence of lymph node (LN) involvement and its prognostic value based on radiological imaging in stage IIB cervical cancer (CC) remains unclear, and evidence regarding oncological outcomes of patients with stage IIB CC with LN metastases is limited. In this study we retrospectively reviewed the incidence and prognostic significance of pretreatment radiologic LN status in 72 patients with clinical stage IIB CC (FIGO 2009), with or without radiologic evidence of LN enlargement. An enlarged LN was defined as a diameter > 10 mm on CT/MRI. Progression-free survival (PFS) and overall survival (OS) were assessed. Radiologic LN enlargement of >10 mm was observed in 45.8% of patients with stage IIB CC. PFS (p = 0.0088) and OS rates (p = 0.0032) were significantly poorer in the LN group (n = 33) than in the non-LN group (n = 39). Univariate Cox analysis revealed that LN > 10 mm contributed to a higher rate of recurrence and mortality. In conclusion, nearly half of the patients with clinical stage IIB CC had enlarged LNs (>10 mm) identified during pretreatment radiologic evaluation, which negatively impacted prognosis. Our findings highlight the need to incorporate CT- or MRI-based LN assessment before treatment for stage IIB CC.

【 授权许可】

Unknown