Precision Medicine Approaches to Cardiac Arrhythmias

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:77

Article

Giudicessi, John R.^1,2,3  Ackerman, Michael J.^2,3,4,5  Fatkin, Diane^6,7,8  Kovacic, Jason C.^6,7,8,9 

[1] Mayo Clin, Clinician Investigator Training Program, Dept Cardiovasc Med, Rochester, MN USA

[2] Mayo Clin, Div Heart Rhythm Serv, Dept Cardiovasc Med, Rochester, MN USA

[3] Mayo Clin, Windland Smith Rice Genet Heart Rhythm Clin, Guggenheim 501, Rochester, MN 55905 USA

[4] Mayo Clin, Div Pediat Cardiol, Dept Pediat & Adolescent Med, Rochester, MN USA

[5] Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[6] Victor Chang Cardiac Res Inst, Lowy Packer Bldg,405 Liverpool St, Darlinghurst, NSW 2010, Australia

[7] Univ New South Wales, St Vincents Clin Sch, Kensington, NSW, Australia

[8] St Vincents Hosp, Cardiol Dept, Sydney, NSW, Australia

[9] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

关键词: Brugada syndrome;    cardiac arrhythmia;    genetic testing;    genetics;    long QT syndrome;    precision medicine;    sudden cardiac death;    atrial fibrillation;   

DOI  :  10.1016/j.jacc.2021.03.325

来源: Elsevier

【 摘 要 】

In the initial 3 papers in this Focus Seminar series, the fundamentals and key concepts of precision medicine were reviewed, followed by a focus on precision medicine in the context of vascular disease and cardiomyopathy. For the remaining 2 papers, we focus on precision medicine in the context of arrhythmias. Specifically, in this fourth paper we focus on long QT syndrome, Brugada syndrome, and atrial fibrillation. The final (fifth) paper will deal with catecholaminergic polymorphic ventricular tachycardia. These arrhythmias represent a spectrum of disease ranging from common to relatively rare, with very different genetic and environmental causative factors, and with differing clinical manifestations that range from almost no consequences to lethality in childhood or adolescence if untreated. Accordingly, the emerging precision medicine approaches to these arrhythmias vary significantly, but several common themes include increased use of genetic testing, avoidance of triggers, and personalized risk stratification to guide the use of arrhythmiaspecific therapies. (J Am Coll Cardiol 2021;77:2573-91) (c) 2021 by the American College of Cardiology Foundation.

【 授权许可】

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