Imaging Systemic Inflammatory Networks in Ischemic Heart Disease

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:65

Review

Nahrendorf, Matthias^1,2  Frantz, Stefan^3,4  Swirski, Filip K.^1,2  Mulder, Willem J. M.^5,6  Randolph, Gwendalyn⁷  Ertl, Georg^3,8  Ntziachristos, Vasilis^9,10  Piek, Jan J.¹¹  Stroes, Erik S.⁶  Schwaiger, Markus¹²  Mann, Douglas L.¹³  Fayad, Zahi A.⁵ 

[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Univ Klinikum Wurzburg, Comprehens Heart Failure Ctr, Wurzburg, Germany

[4] Univ Klinikum Halle, Univ Klin & Poliklin Innere Med 3, Halle, Saale, Germany

[5] Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

[6] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands

[7] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[8] Univ Klinikum Wurzburg, Med Klin & Poliklin 1, Wurzburg, Germany

[9] Tech Univ Munich, Inst Biol & Med Imaging, Neuherberg, Germany

[10] Helmholtz Zentrum Munchen, Neuherberg, Germany

[11] Univ Amsterdam, Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

[12] Tech Univ Munich, Klinikum Rechts Isar, Dept Nucl Med, D-80290 Munich, Germany

[13] Washington Univ, Sch Med, Dept Med, Ctr Cardiovasc Res,Div Cardiol, St Louis, MO 63110 USA

关键词: atherosclerosis;    heart failure;    hematopoiesis;    leukocytes;    myocardial infarction;    spleen;   

DOI  :  10.1016/j.jacc.2015.02.034

来源: Elsevier

【 摘 要 】

While acute myocardial infarction mortality declines, patients continue to face reinfarction and/or heart failure. The immune system, which intimately interacts with healthy and diseased tissues through resident and recruited leukocytes, is a central interface for a global host response to ischemia. Pathways that enhance the systemic leukocyte supply may be potential therapeutic targets. Pre-clinically, imaging helps to identify immunity's decision nodes, which may serve as such targets. In translating the rapidly-expanding pre-clinical data on immune activity, the difficulty of obtaining multiple clinical tissue samples from involved organs is an obstacle that whole-body imaging can help overcome. In patients, molecular and cellular imaging can be integrated with blood-based diagnostics to assess the translatability of discoveries, including the activation of hematopoietic tissues after myocardial infarction, and serve as an endpoint in clinical trials. In this review, we discuss these concepts while focusing on imaging immune activity in organs involved in ischemic heart disease. (C) 2015 by the American College of Cardiology Foundation.

【 授权许可】

Free