Aortopathy Is Prevalent in Relatives of Bicuspid Aortic Valve Patients

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:53

Article

Biner, Simon^1,2  Rafique, Asim M.¹  Ray, Indraneil¹  Cuk, Olivera¹  Siegel, Robert J.¹  Tolstrup, Kirsten¹ 

[1] Cedars Sinai Med Ctr, Inst Heart, Los Angeles, CA 90048 USA

[2] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Cardiol, IL-69978 Tel Aviv, Israel

关键词: aorta;    echocardiography;    genetics;    valves;   

DOI  :  10.1016/j.jacc.2009.03.027

来源: Elsevier

【 摘 要 】

Objectives This study aimed to determine the prevalence of dilation and abnormal elastic properties of aortic root in first-degree relatives (FDRs) of bicuspid aortic valve (BAV) patients. Background Evidence indicates that BAV is a genetic disorder. Although FDRs of affected individuals have an increased prevalence of BAV, their risk of aortic root abnormalities is unknown. Methods We studied dimensions as well as the elastic properties of the ascending aorta in 48 FDRs with morphologically normal tricuspid aortic valves, 54 BAV patients, and 45 control subjects using 2-dimensional echocardiography. Results The prevalence of aortic root dilation was 32% in FDRs and 53% in BAV patients, whereas all control subjects showed normal aortic dimensions (p < 0.001). The FDRs and BAVs had significantly lower aortic distensibility (1.7 +/- 1.4 x 10(-3) mm Hg and 1.4 +/- 2.0 x 10(-3) mm Hg vs. 2.5 +/- 1.6 x 10(-3) mm Hg, p < 0.001) and greater aortic stiffness index (26.7 +/- 25.8 and 55.9 +/- 76.8 vs. 18.7 +/- 40.1, p = 0.001) compared with control subjects. This difference remained significant in subjects without aortic root dilation or hypertension (p = 0.002 and p = 0.004, respectively). Conclusions The aortic root is functionally abnormal and dilation is common (32%) in first-degree relatives of patients with BAV. Screening of FDRs by transthoracic 2-dimensional echocardiography should be considered for detection of aortic valve malformation and dilated ascending aorta. (J Am Coll Cardiol 2009; 53: 2288-95) (C) 2009 by the American College of Cardiology Foundation

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