Monocyte and Macrophage Dynamics in the Cardiovascular System JACC Macrophage in CVD Series (Part 3)

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:72

Review

Fayad, Zahi A.^1,2,3  Swirski, Filip K.^4,5  Calcagno, Claudia^1,2  Robbins, Clinton S.^4,5,6,7,8  Mulder, Willem^1,2  Kovacic, Jason C.³ 

[1] Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Radiol, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

[4] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[5] Harvard Med Sch, Boston, MA USA

[6] Univ Hlth Network, Toronto Gen Res Inst, Peter Munk Cardiac Ctr, Toronto, ON, Canada

[7] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[8] Univ Toronto, Dept Immunol, Toronto, ON, Canada

关键词: atherosclerosis;    bone marrow;    cardiovascular;    imaging;    macrophage;   

DOI  :  10.1016/j.jacc.2018.08.2150

来源: Elsevier

【 摘 要 】

It has long been recognized that the bone marrow is the primary site of origin for circulating monocytes that may later become macrophages in atherosclerotic lesions. However, only in recent times has the complex relationship among the bone marrow, monocytes/macrophages, and atherosclerotic plaques begun to be understood. Moreover, the systemic nature of these interactions, which also involves additional compartments such as extramedullary hematopoietic sites (i.e., spleen), is only just becoming apparent. In parallel, progressive advances in imaging and cell labeling techniques have opened new opportunities for in vivo imaging of monocyte/macrophage trafficking in atherosclerotic lesions and at the systemic level. In this Part 3 of a 4-part review series covering the macrophage in cardiovascular disease, the authors intersect systemic biology with advanced imaging techniques to explore monocyte and macrophage dynamics in the cardiovascular system, with an emphasis on how events at the systemic level might affect local atherosclerotic plaque biology. (c) 2018 by the American College of Cardiology Foundation.

【 授权许可】

Free