Modular synthesis of non-conjugated N-(quinolin-8-yl) alkenyl amides via cross-metathesis

TETRAHEDRON

卷:93

Article

Ni, Hui-Qi¹  Li, Zi-Qi¹  Tran, Van T.¹  Engle, Keary M.¹ 

[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

关键词: Alkenes;    Alkene functionalization;    Directing group;    Olefin metathesis;    Grubbs catalyst;   

DOI  :  10.1016/j.tet.2021.132279

来源: Elsevier

【 摘 要 】

We report a direct and modular method to access non-conjugated alkenyl amides containing the 8-aminoquinoline (AQ) directing auxiliary and related groups via cross-metathesis. In this way, readily available, AQ-containing, terminal beta, gamma-unsaturated amides can be coupled with various terminal alkenes to furnish internal alkene products that are otherwise difficult to prepare. The value of this family of products stems from their ability to participate in a number of directed alkene functionalization reactions. (C) 2021 Published by Elsevier Ltd.

【 授权许可】

Free