Alkoxy-directed cyclopropanation of 1,1-disubstituted alkenes with esters: new approach to quaternary carbon centers

TETRAHEDRON LETTERS

卷:56

Article

Rao, Nagavaram Narsimha¹  Cha, Jin Kun¹ 

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

关键词: Cyclopropanation;    Cyclopropanol;    Homoenol;    Directing group;    Quaternary center;   

DOI  :  10.1016/j.tetlet.2014.12.043

来源: Elsevier

【 摘 要 】

As a new approach to the stereocontrolled construction of quaternary centers, 1,2,2-trisubstituted cyclopropanols are prepared by the olefin exchange-mediated Kulinkovich cyclopropanation of esters with 1,1-disubstituted alkenes bearing homoallylic alcohols. Central to the successful cyclopropanation is the generation of a temporary alkoxy tether from a homoallylic alcohol. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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