Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas

TETRAHEDRON

卷:69

Article

Yang, Miao¹  Odelberg, Shannon J.^2,3,4  Tong, Zongzhong⁴  Li, Dean Y.^2,3,5,6,7  Looper, Ryan E.¹ 

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Med, Div Cardiol, Salt Lake City, UT 84132 USA

[3] Univ Utah, Program Mol Med, Salt Lake City, UT 84112 USA

[4] Navigen Inc, Salt Lake City, UT 84108 USA

[5] Univ Utah, Dept Oncol, Salt Lake City, UT 84112 USA

[6] Sichuan Acad Med Sci, Inst Lab Med, Key Lab Human Dis Study Sichuan Prov, Chengdu 610072, Sichuan, Peoples R China

[7] Sichuan Prov Peoples Hosp, Chengdu 610072, Sichuan, Peoples R China

关键词: Dihydropyrimidone;    Heterocycle;    Hydroamination;    Rhodium catalysis;    ARF 6;   

DOI  :  10.1016/j.tet.2013.04.071

来源: Elsevier

【 摘 要 】

Cationic Rh(II) complexes are able to catalyze the regioselective hydroamination of propargyl ureas in a 6-endo fashion. This transformation permits access to interesting substitution patterns of dihydropyrimidines, which have found use as nucleotide exchange factor inhibitors. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free