Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

TETRAHEDRON

卷:67

Article

Lamaty, Frederic¹ 

[1] Univ Montpellier I, Inst Biomol Max Mousseron, UMR 5247, F-34095 Montpellier 05, France

关键词: Ball-mill;    Solvent-free synthesis;    Green chemistry;    Protected hydrazones;    Condensation;    Alkylation;   

DOI  :  10.1016/j.tet.2011.07.056

来源: Elsevier

【 摘 要 】

A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free