Solvent-free synthesis of unsaturated amino esters in a ball-mill

TETRAHEDRON LETTERS

卷:51

Article

Lamaty, Frederic¹ 

[1] Univ Montpellier I, CNRS, Inst Biomol Max Mousseron, UMR 5247, F-34095 Montpellier 05, France

关键词: Ball-mill;    Solvent-free;    Amino acid;    Horner-Wadsworth-Emmons;    Olefination;    Dehydroalanine;    Carbonate base;    Phosphonate;   

DOI  :  10.1016/j.tetlet.2010.09.069

来源: Elsevier

【 摘 要 】

The ball-milling technique was used under solvent-free conditions to perform a Horner-Wadsworth-Emmons reaction in the presence of a mild carbonate base. Starting from a phosphonate-substituted glycine, this method gave access to Boc-protected unsaturated amino esters in excellent yield and selectivity in many cases. The scope of the reaction was delineated. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

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