Stereoselective synthesis of a C1-C18 fragment of amphidinolides G and H

TETRAHEDRON

卷:69

Article

Garcia-Fortanet, Jorge^1,2  Formentin, Pilar¹  Diaz-Oltra, Santiago¹  Murga, Juan¹  Carda, Miguel¹  Alberto Marco, J.³ 

[1] Univ Jaume 1, Dept Q Inorgon & Organ, Castellon de La Plana 12071, Spain

[2] Novartis Inst BioMed Res, Cambridge, MA 02139 USA

[3] Univ Valencia, Dept Q Organ, E-46100 Valencia, Spain

关键词: Macrolides;    Amphidinolides;    Julia-Kocienski olefination;    Stille coupling;    Ohira-Bestmann reaction;    Alkyne silylstannation;   

DOI  :  10.1016/j.tet.2013.02.062

来源: Elsevier

【 摘 要 】

A stereoselective synthesis of a C1-C18 segment of the structure of the cytotoxic macrolides amphidinolides G and H is reported. The target compound was retrosynthetically disconnected into three fragments. In the synthetic sense, connection of the fragments was made by means of a Stille coupling and a Julia-Kocienski olefination. Precursors from the chiral pool were used as the starting materials. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free