1,2,3-Triazole amine as directing group in promoting catalytic oxidative C-H olefination under aerobic conditions

TETRAHEDRON

卷:72

Article

Ye, Xiaohan¹  Zhang, Yanwei²  He, Ying¹  Shi, Xiaodong¹ 

[1] Univ S Florida, Dept Chem, 4202 E Fowler Ave, Tampa, FL 33620 USA

[2] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

关键词: C-H activation;    1,2,3-Triazole;    Oxidative heck;    Aerobic olefination;    Directing group;   

DOI  :  10.1016/j.tet.2016.02.013

来源: Elsevier

【 摘 要 】

A practical ortho C-H olefination of phenyl acetic acid derivatives was achieved with a 1,2,3-triazole auxiliary directing group. Good to excellent yields were achieved with 02 as terminal oxidant. Other bidentate directing groups, such as 8-aminoquinoline, gave poor reactivity under this aerobic condition, highlighting the unique reactivity of triazole in promoting C-H activation. (C) 2016 Published by Elsevier Ltd.

【 授权许可】

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